ORIGINAL ARTICLE: Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers

Published July 8, 2009, 2:42 pm, New England Journal of Medicine

Inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP), a key enzyme for the repair of breaks in DNA, can lead to the accumulation of breaks in double-stranded DNA. The BRCA1 and BRCA2 proteins help to repair such breaks. In this phase 1 trial, the PARP inhibitor olaparib was shown to lack the severe toxic effects of conventional chemotherapy and to result in objective ...

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