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Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. Now, a report in the July 10 issue of the journal Cell, a Cell Press publication, offers new insight into the bugs' talent for meager living.
Scientists have created an experimental model that produces large-scale expansion of GAA repeats during DNA replication, which is the cause of Friedreich's Ataxia. With this model, the researchers are able to analyze GAA repeat expansions and then identify cellular proteins that thwarted normal replication and promoted the elongated sequence.
Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. Now, scientists offer new insights into the bugs' talent for meager living.
Researchers in human genetics have long known that expansions of GAA repeats – resulting in this nucleotide triplet repeating hundreds or thousands of times – cause the most common hereditary neurological disorder known as Friedreich's ataxia.
Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl.
Researchers in human genetics have long known that expansions of GAA repeats - resulting in this nucleotide triplet repeating hundreds or thousands of times - cause the most common hereditary neurological disorder known as Friedreich's ataxia. There is no cure for this condition, which damages the nervous system and can result in heart disease.
A Tufts University research team has created an experimental model that produces large-scale expansion of GAA repeats during DNA replication, which is the cause of Friedreich's Ataxia. With this model, the researchers are able to analyze GAA repeat expansions and then identify cellular proteins that thwarted normal replication and promoted the elongated sequence.
DUBLIN----Research and Markets has announced the addition of the "Therapeutic Peptides in Oncology: Drug Pipeline Update 2009" report to their offering.
Scientists in Japan are reporting development of a faster, less expensive version of the fabled polymerase chain reaction (PCR), a DNA test widely used in criminal investigations, disease diagnosis, biological research and other applications. The new method could lead to expanded use of PCR in medicine, the criminal justice system and elsewhere, the researchers say.
Washington, July 9 : Scientists in Japan have developed a faster, cheaper and better DNA test for criminal investigations, diagnostics and other applications, according to the latest research.
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